Second Patient Dies After Genetically Altered Pig Heart Transplant
How Pig Hearts Are Genetically Altered Genetically altered pig hearts are created by editing the DNA of pigs using a gene editing technology called CRISPR-Cas9. This technology allows scientists to insert, delete, or change specific genes in an organism's DNA. To create a genetically altered pig heart for transplant, scientists typically make the following changes: They inactivate genes that code for proteins that trigger an immune response in humans. They insert genes that code for human proteins that help to suppress the immune response and promote organ acceptance. They inactivate genes that control the growth of the pig heart, so that it does not overgrow after transplant. The Science Behind Genetically Altered Pig Heart Transplants Genetically altered pig heart transplants are a type of xenotransplantation, which is the transplantation of organs or tissues from one species to another. Xenotransplantation has been a goal of medical science for many years, but it has been hamper...