DIFFICULT CHOICE: Avoid Pain or Damage Kidneys?
DIFFICULT CHOICE: Avoid Pain or Damage Kidneys? All non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with the development of acute kidney injury Heavy or long-term use of some of these medicines, such as ibuprofen, naproxen, and higher dose aspirin, can cause chronic kidney disease known as chronic interstitial nephritis NSAIDs can cause two different forms of acute kidney injury. Haemodynamically mediated (eg, pre-renal injury and/or acute tubular necrosis). !? Immune mediated (eg, acute interstitial nephritis). Acute kidney injury represents a continuum of renal injury ranging from clinically asymptomatic changes in renal function to renal failure and death. Acute kidney injury is characterised by a rapid fall in glomerular filtration rate (GFR) over hours to days In the general population, the pooled odds ratio (OR) of AKI for current NSAID exposure was 1.73 (95%CI 1.44 to 2.07), with somewhat higher risk observed in older people (OR 2.51, 95%CI 1.52 to 2.68). In ...